Custom Peptides
Cayman Chemical NDSmethyltamoxIfenhydroch 10mg
An active metabolite of tamoxifen; inhibits PKC (IC50 = 8 µM for the rat enzyme); decreases iron (III) chloride and ascorbate-induced increases in TBARS in rat liver microsomes (IC50 = 17.5 µM); induces relaxation in isolated and washed rat aortic rings (pD2 = 9)
Cayman Chemical 4hydroxy DIPThydroCLOrID 10mg
An analytical reference standard categorized as a tryptamine; induces the HTR in mice; substitutes for DOM in a two-lever drug discrimination test in rats; intended for research and forensic applications
Cayman Chemical MtAhydrochlorIde 10mg
A designer drug that features a carbonyl group adjacent to a phenyl group, similar to cathinones; also marketed as mephtetramine; intended for forensic and research applications
Cayman Chemical Skepnon-L 10mg
An ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 µM); has little effect on a range of other kinases, including p38γ and p38δ; blocks the phosphorylation of HSP27, a p38 MAPK substrate, in response to stimulation with anisomycin in HeLa cells (IC50 = 25 nM)
Cayman Chemical AlflutInIbmesylate 10mg
An inhibitor of mutant EGFRs; selective for EGFRL858R, EGFRG719X, EGFRL858R, EGFRL861A, and EGFRT790M mutant EGFRs over wild-type EGFR; reduces tumor growth in an EGFRL858R and EGFRT790M-expressing LU1868 NSCLC PDX mouse model at 10 and 30 mg/kg
Cayman Chemical BrIncIdofovIr 10mg
A prodrug form of cidofovir; inhibits CMV, HSV-1, HSV-2, cowpox, and vaccinia virus replication in plaque reduction assays (EC50s = 0.0009, 0.06, 0.08, 0.6, and ~1 µM, respectively); decreases mortality in mouse models of cowpox or vaccinia virus infections at 6.7 or 5 mg/kg, respectively
Cayman Chemical EdonrpIcmaleate 10mg
A neurotrophic agent; protects against sodium nitroprusside-induced mitochondrial dysfunction and apoptosis in primary rat cortical neurons at 0.1 and 1 µM; prevents Aβ40-induced granule cell loss and improves performance in the distance movement, random reward place search, and place learning tasks in rats at 8.4 mg/kg; increases hippocampal neurogenesis and ameliorates Aβ40-induced spatial learning impairments in a rat model of Alzheimer’s disease
Cayman Chemical GusacItInIb 10mg
A dual inhibitor of JAKs (IC50s = 46, 4, and 11 nM for JAK1-3, respectively) and Syk family kinases (IC50s = 5 and 8 nM for SyK and TYK2, respectively)
Cayman Chemical EmodIn 8-glucosIde 10mg
An anthraquinone glycoside; inhibits the activities of rat lens aldose reductase and human DNA topoisomerase II (IC50s = 14.4 and 66 μM, respectively, in cell-free assays); promotes the proliferation and differentiation of mouse MC3T3-E1 osteoblastic cells at 1 ng/ml; decreases infarct size in a rat model of focal cerebral ischemia and reperfusion injury at 5 mg/kg
Cayman Chemical Gabexatemesylate 10mg
A competitive inhibitor of serine proteases; inhibits human thrombin, urokinase, plasmin, and Factor Xa (Kis = 0.97, 1.3, 1.6, and 8.5 μM, respectively); inhibits bovine thrombin, Factor Xa, and trypsin, and porcine plasma kallikrein (Kis = 1.4, 2.1, 2.6, and 0.2 μM, respectively); inhibits clotting activity of human thrombin (IC50 = 10 μM); inhibits fibrin formation in rats (continuous infusion of 120 μmol/kg per hour)
Cayman Chemical GlucosdePNdent Insulnotro 10mg
A pro-atherogenic peptide; induces IκB-α degradation and NF-κB nuclear translocation in macrophage-differentiated THP-1 cells and isolated human aortic endothelial cells at 1 µM; increases atherosclerotic lesion area and plaque formation in ApoE-/- mice
Cayman Chemical RemoxIprIdehydrochlorIde 10mg
An atypical antipsychotic and dopamine D2 receptor antagonist (Ki = 0.2 µM); selective for the D2 receptor over a panel of 33 receptors, neurotransmitter transporters, and ion channels at 10 µM but does inhibit the σ receptor (Ki = 0.065 µM); increases striatal DOPAC and HVA levels in rats from 2-20 µmol/kg; inhibits apomorphine-induced stereotypy and hyperactivity in rats (ED50s = 5.6 and 0.8 µmol/kg, respectively)
Cayman Chemical 17phenl trInor ProstglndI 10mg
A metabolically stable analog of PGF2α and potent FP receptor agonist (Ki = 1.1 nM at the rat FP receptor)
Cayman Chemical 5-ndrostentrIol 10mg
An active metabolite of DHEA; reduces radiation-induced lethality and induces hematopoietic recovery from surviving stem cells in mice at 0.75 mg/25 g body weight; increases survival in a rat model of surgical trauma-induced sepsis at 40 mg/kg; urinary levels are increased in women with androgenic alopecia